ANTICOAGULANT SOLUTIONS

Aug. 07, 2017


ANTICOAGULANT SOLUTIONS USED IN BLOOD BAG

Solution

Purpose

Whole blood/Red cell Storage Period

Additive Concentrations            

             (per 100ml)

Performance

CPD

Anticoagulation and storage of blood

21 days

Citric Acid (Anhydrous)

0.299 g

Ÿ Prevent coagulation of blood

Sodium Citrate (Dihydrate)

2.63 g

Ÿ Adjust pH

Monobasic Sodium Phosphate (Monohydrate)

0.222 g

Ÿ Nutrition source for red cell

Dextrose (Monohydrate)

2.55 g

Ÿ Supports ATP production

Water for injection 

q.s.100 ml


CPDA 1

Anticoagulation and storage of blood

35 days

Citric Acid (Anhydrous)

0.299 g

Ÿ Prevent coagulation of blood

Sodium Citrate (Dihydrate)

2.63 g

Ÿ Adjust pH

Monobasic Sodium Phosphate (Monohydrate)

0.222 g

Ÿ Nutrition source for red cells

Dextrose (Monohydrate)

3.19 g

Ÿ Support ATP production

Adenine

0.0275 g

Ÿ Supports to maintain ATP level

Water for injection

q.s.100 ml

in red cell

SAGM

Red cell preservation

42 days

Dextrose (monohydrate)

0.900 g

Ÿ Nutrition source for red cells

Sodium chloride

0.877 g

Ÿ Adjusts osmotic pressure

Adenine

0.0169 g

Ÿ Supports to maintain ATP level

D-mannitol

0.525 g

in red cell

Water for injection

q.s.100 ml

Ÿ Supports integrity of red cell



membrane (to avoid haemolysis)